YMC — Preparative Chromatography Systems, Columns and Packing Materials
Global supply of preparative chromatography systems, high-resolution DAC columns, and advanced packing materials by YMC (Japan / YMC CO., LTD.). Contichrom continuous twin-column systems, industrial K-Prep HPLC units, and YMC-Triart Prep hybrid silica media from SpareX.
YMC Contichrom and K-Prep Preparative Chromatography Systems
Continuous Contichrom CUBE and TWIN systems utilize twin-column MCSGP and CaptureSMB technologies. Industrial K-Prep HPLC units enable seamless purification scale-up for peptides and proteins. Systems include high-pressure pump modules and automated multi-position valves.
- Twin-column Contichrom CUBE platforms and industrial K-Prep HPLC units
- Purification of synthetic peptides, recombinant proteins, and mAbs
- Continuous MCSGP separation with throughput up to hundreds of kilograms
- High-pressure pump heads, column frits, and automated multi-position valves
YMC DAD Dynamic Axial Compression and Actus Preparative Columns
Dynamic axial compression DAD columns and semi-preparative YMC-Actus hardware maintain uniform bed packing. This design prevents void formation and extends the operational lifetime of media. Assemblies support chiral purifications and pharmaceutical synthesis.
- DAC columns DAD series and semi-preparative YMC-Actus hardware
- Preparative fractionation of active pharmaceutical ingredients and isomers
- Internal diameters from 20 to 1000 mm with pressure ratings up to 30 MPa
- Replaceable distribution frits, piston PTFE seals, and end-fitting flanges
YMC-Triart Prep Hybrid Sorbent and YMC-GEL Spherical Silica Media
YMC-Triart Prep bulk media utilize organic-inorganic hybrid silica engineered for stable operation at pH 1 to 12. Spherical YMC-GEL provides superior chromatographic selectivity and mechanical bed stability. Sorbents withstand rigorous clean-in-place CIP cycles using sodium hydroxide.
- Hybrid sorbents YMC-Triart Prep C18, Bio C4, and spherical YMC-GEL
- Scale-up purification of synthetic peptides, oligos, and small molecules
- Wide pH range 1 to 12, particle sizes 10, 15, 20 um and pores 12, 20 nm
- Bulk packing media, slurry packing adapter kits, and distribution mesh
YMC BioPro IEX Polymeric Ion Exchange Media for Biomolecules
Polymeric BioPro IEX SmartSep Q and S media deliver high-throughput purification of proteins and antibodies. They provide high dynamic binding capacity exceeding 100 mg per ml with low bed backpressure. Sorbent beads withstand high linear velocities in large process-scale chromatography columns.
- Polymeric ion exchange media BioPro IEX SmartSep Q, S, and BioPro HIC
- Purification of monoclonal antibodies, industrial enzymes, and ADCs
- Dynamic binding capacity exceeding 100 mg/mL at elevated flow velocities
- Process resins, mobile phase flow distributors, and sanitary tri-clamps
YMC Chiral Art Preparative Columns and Polysaccharide Media
Chiral Art immobilized polysaccharide sorbents enable resolution of optical enantiomers. Amylose-C and Cellulose-C phases offer broad compatibility across organic mobile phases. Assemblies deliver high preparative separation efficiency for active isomers.
- Immobilized and coated chiral media Chiral Art Amylose and Cellulose
- Preparative resolution of optical enantiomers and chiral active ingredients
- Extended chemical compatibility with THF, chloroform, and ethyl acetate
- Guard column cartridges, column end-fittings, and fluid distributor frits
YMC Preparative HPLC Pump Modules and Fluidic Switching Valves
High-pressure precision pump modules deliver pulseless eluent flow across wide preparative flow rate ranges. Automated multi-position switching valves ensure accurate gradient formation and reliable fraction collection. Flow path components are constructed from corrosion-resistant alloys and PEEK.
- Preparative high-pressure pump modules and multi-port switching valves
- Binary and quaternary gradient blending for industrial-scale HPLC systems
- Flow rates from 10 mL/min to 50 L/h with pressure limits up to 50 MPa
- Sapphire plungers, dynamic PTFE seals, and ceramic check valve cartridges
YMC Preparative Chromatography Systems and Separation Architecture
Japanese corporation YMC CO., LTD. develops and manufactures high-performance chromatography columns, bulk packing materials, and industrial preparative purification systems.
The product portfolio includes continuous twin-column Contichrom CUBE and TWIN platforms alongside industrial-scale K-Prep HPLC complexes designed for peptide synthesis, oligonucleotide purification, and recombinant antibody downstream processing.
The engineering program features continuous multicolumn countercurrent solvent gradient purification MCSGP, dynamic axial compression DAD columns with internal diameters up to 1000 mm, alkaline-stable hybrid silica sorbents YMC-Triart Prep operating across pH 1 to 12, and hydrophilic polymeric BioPro IEX resins engineered for large-scale biopharmaceutical manufacturing.
Preparative Column Dynamic Axial Compression and Scale-Up Protocols
Packing preparative YMC columns with Triart Prep and YMC-GEL media employs dynamic axial compression DAC technology under continuous hydraulic pressures up to 30 MPa.
This hydraulic piston mechanism prevents void formation, preserves bed homogeneity, and delivers repeatable peak symmetry during high-throughput purification of active pharmaceutical ingredients.
Clean-in-place CIP sanitization protocols allow column washing with 0.1 to 1.0 M sodium hydroxide solution without phase degradation or bonded ligand stripping.
SpareX engineering teams assist with stationary phase selection, fluidic valve configuration audits, and reliable global delivery of verified YMC chromatography hardware with factory QC inspection reports.
YMC and model names are trademarks of their respective owners and are used only to identify the equipment for which we source parts. SpareX is not an official dealer, distributor or representative of YMC and is not affiliated with the trademark owner. Origin, documents and warranty are stated for each item in the quotation.
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Documents and sources
- Official YMC website — preparative columns, packing materials and chromatography systems
- Corporate outline and holding structure of YMC CO., LTD. — global subsidiaries
- YMC corporate history — milestone launch of YMC-GEL media and YMC-Pack columns
- Continuous twin-column preparative chromatography systems Contichrom CUBE
- Industrial preparative HPLC systems K-Prep series — purification scale-up
- Hybrid packing material YMC-Triart Prep — organic-inorganic silica pH 1 to 12
- BioPro IEX polymeric ion exchange media — purification of proteins and antibodies
- Chinese subsidiary YMC Biotech Changzhou Co., Ltd. — Asian sales and technical service
