Bulk Silica Gel, Chromatography Media, and Metal Scavengers SiliCycle / SiliCycle Inc.

High-purity SiliaFlash irregular silica, SiliaSphere spherical media, SiliaMetS metal scavengers, and SiliaSep cartridges manufactured in Canada by SiliCycle Inc. for preparative chromatography and API synthesis.

SiliaFlash Irregular Silica Gels

SiliaFlash irregular silica gels manufactured by SiliCycle Inc. in Canada are engineered for preparative flash chromatography and industrial scale purification of organic molecules. The material provides tightly controlled 60 angstrom porosity and an ultra-low fines percentage.

Ultra-pure SiliaFlash P60 bare silica matrix with 60 angstrom pores
Particle distribution 40 to 63 microns (230 to 400 mesh) for flash
Ultra-low trace metal content and strictly controlled neutral pH
Bulk drums from 1 kg up to hundreds of kilograms with complete CoA

SiliaSphere Spherical Silica Gels

SiliaSphere spherical silica gels by Canadian manufacturer SiliCycle are designed for high-resolution preparative liquid chromatography and large-scale pharmaceutical separations. Monodisperse spherical particles ensure dense column bed packing and dependable reproducibility.

Monodisperse spherical matrix with pore ratings of 60, 100, 120, 300 A
Particle sizes spanning 3, 5, 10, 15, and 20 microns for HPLC and DAC
Reversed-phase bonded chemistries: C18, C8, C4, Phenyl, Amine, Diol
High mechanical strength withstanding axial compression up to 100 bar

SiliaMetS Metal Scavengers

SiliaMetS functionalized silica metal scavengers from SiliCycle deliver selective binding and extraction of residual transition metal catalysts. The scavengers reliably reduce levels of palladium, platinum, ruthenium, and nickel in active pharmaceutical ingredients per ICH Q3D.

Selective scavenging of residual catalyst metals Pd, Pt, Ru, Rh, Cu, Ni
Full compliance with ICH Q3D elemental impurity regulatory limits
Bonded functional ligands including Thiol, DMT, Triamine, Imidazole
Consistently reduces residual catalyst concentrations in API below 1 ppm

SiliaSep Flash Chromatography Cartridges

SiliaSep pre-packed flash chromatography cartridges by SiliCycle deliver reproducible preparative purification for challenging synthetic reaction mixtures. The cartridges feature robust pressure ratings, leak-free construction, and full compatibility with flash systems.

Cartridge formats spanning from 4 grams up to 3.3 kilograms of media
Direct hardware compatibility with Teledyne Isco, Biotage, Buchi units
Loaded with standard SiliaFlash or high-capacity spherical SiliaSphere
High operating burst pressure rating up to 14 bar with leak-free seals

SiliaBond Functionalized Silica Reagents

SiliaBond functionalized silica matrices by SiliCycle provide versatile solid-supported reagents and heterogeneous catalysts for synthetic chemistry. They simplify workup workflows, accelerate reaction kinetics, and eliminate laborious solvent extraction steps.

Bonded functional groups: carboxylic acids, tosic acids, amines, thiols
SiliaCat heterogeneous catalysts for Suzuki and cross-coupling reactions
Solid-phase extraction (SPE) cartridges and organic impurity catchers
Excellent swelling resistance in polar and non-polar organic solvents

SiliaPrep SPE Cartridges and Well Plates

SiliaPrep solid-phase extraction cartridges and 96-well plates by SiliCycle Inc. are engineered for sample preparation and clean-up of biological and environmental matrices. Silica-based and polymeric sorbents ensure high extraction recoveries without leachable contaminants.

SiliaPrep extraction cartridge formats from 1 mL to 276 mL capacity
SiliaPrepX 96-well plates optimized for high-throughput robotics
Normal phase, reversed-phase, and ion-exchange sorbent chemistries
High recovery and clean background for HPLC, GC, and LC-MS assays

SiliaFlash Irregular Silica Gels for Scalable Preparative Purification

Specialized milling and air-classification technologies deliver a narrow 40 to 63 micron particle size distribution that minimizes column backpressure while maximizing sample throughput.

Strictly neutral pH and low heavy metal impurities prevent decomposition of acid-labile pharmaceutical intermediates during flash separations.

SiliaSphere Spherical Matrix for High-Resolution HPLC and DAC Columns

Media are available in pore diameters of 60, 100, 120, and 300 angstroms to purify small synthetic APIs as well as biomacromolecules including polypeptides and oligonucleotides.

Outstanding mechanical particle strength withstands dynamic axial compression (DAC) column compaction up to 100 bar without granule attrition.

Binding Chemistries and Selectivity of SiliaMetS Metal Scavengers

SiliaMetS functionalized silica metal scavengers from SiliCycle deliver selective binding and extraction of residual transition metal catalysts.

The scavengers reliably reduce levels of palladium, platinum, ruthenium, and nickel in active pharmaceutical ingredients per ICH Q3D. Covalent attachment of chelating ligands such as Thiol, Triamine, Imidazole, and Cysteine onto high-surface silica matrices prevents organic leaching into target product streams.

Scavengers operate efficiently both as bulk reaction slurries followed by filtration and in packed flow-through cartridges for continuous API processing.

Multi-Ton Scale Manufacturing Capability at Quebec City Headquarters

Built in 2009 and located in Quebec City (Canada), the SiliCycle Headquarters is a cutting-edge plant with a multi-ton scale manufacturing capability. Automated production lines ensure high batch-to-batch consistency with precise control over pore diameter and particle dimensions.

State-of-the-art analytical equipment including mass spectrometry, X-ray fluorescence, and preparative chromatography ensures complete quality qualification before shipping to industrial customers in more than 75 countries worldwide.

ISO 9001 Quality System and Multi-Vendor Pharmaceutical Audits

Operating under an ISO 9001 quality system, SiliCycle maintains a rigorous quality management structure with documented operational procedures across all synthesis stages. In 2012, SiliCycle was the first facility to pass a comprehensive vendor audit by AstraZeneca with a perfect score of 100 %.

Every dispatched batch of silica gel and SiliaMetS scavenger is accompanied by an extensive Certificate of Analysis (CoA) detailing particle sizing, surface area, pore volume, metal assays, and chromatographic marker resolution testing.

Technical Media Selection via TDS and SDS Verification Guidelines

Technical selection of SiliCycle chromatography media is performed against technical data sheets and safety specifications to calculate bed volumes and bulk batch requirements.

Application specialists evaluate matrix morphology, pore dimensions, metal scavenging capacity, and organic solvent compatibility. For evaluation trials, qualification sample kits and pilot batches are supplied prior to commercial drum deliveries under sealed factory packaging.

SiliCycle / SiliCycle Inc. and model names are trademarks of their respective owners and are used only to identify the equipment for which we source parts. SpareX is not an official dealer, distributor or representative of SiliCycle / SiliCycle Inc. and is not affiliated with the trademark owner. Origin, documents and warranty are stated for each item in the quotation.

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